Magnesium L-Threonate: Health Benefits, Dose and Side Effects

Magnesium L-Threonate: Health Benefits, Dose and Side Effects

Have you ever experienced those frustrating moments when your mind seems to falter and you struggle to recall simple things like where you placed your keys or the name of someone you just met? Perhaps you've found yourself reading an article or book, only to realize later that you can't quite remember what it was about. If you've encountered these memory lapses, you're not alone. And interestingly, it may not be solely attributed to ageing. In our increasingly complex and technologically-driven world, our brains often find themselves overwhelmed by the sheer volume of information we process daily. That's where magnesium, specifically Magnesium L-threonate, comes into play. By nourishing and supporting our brain health, this unique form of magnesium can enhance cognitive function and provide a much-needed boost to our overloaded minds.


Dr. Ayesha Tufail

Certified Medical Doctor, Researcher and Top-Rated Medical Writer on Upwork. Dr. Ayesha Tufail has more than 10 years of experience working as a General Practitioner. Her areas of research include Stem Cell Therapy, Herbal Health Supplements & Adult ADHD.

You can get in touch with Dr. Ayesha via her LinkedIn account linked at the end of this page. 

What is Magnesium L-Threonate?

Magnesium is a crucial mineral in the body, involved in numerous enzyme processes and essential for overall health. While various forms of magnesium, such as citrate and glycinate, exist, their limited absorption hampers their potential cognitive benefits. To address this issue, researchers at the Massachusetts Institute of Technology (MIT) developed a solution: Magnesium L-threonate. This unique formulation, derived from the salt of threonic acid, exhibits superior absorption, with studies suggesting an increase in absorption rates by approximately 15%. This enhanced bioavailability makes Magnesium L-threonate a promising option for supporting brain health and cognitive function.


Health Benefits of Magnesium L-Threonate

Magnesium L-threonate offers several health benefits, particularly in relation to brain health and cognitive function. Here are detailed explanations of its potential advantages: 

  • Increase Magnesium Level in Brain

Magnesium L-threonate stands out for its remarkable ability to increase magnesium levels in the brain, thanks to its unique molecular structure. Through its chelation with L-threonic acid, this compound becomes highly lipophilic, facilitating its smooth passage across cell membranes and the blood-brain barrier. As a result, a greater concentration of magnesium is delivered directly to the brain cells, maximizing its potential to support cognitive function and promote overall brain health. By ensuring an ample supply of magnesium to the brain, Magnesium L-threonate holds great promise in harnessing the benefits of this essential mineral for optimal brain performance and well-being.

  •  Improves Cognitive Function of Brain

Magnesium L-threonate has been studied for its potential to improve cognitive function and enhance brain health. By increasing brain magnesium levels, it supports various mechanisms that contribute to cognitive enhancement:

  • Synaptic Plasticity

Magnesium L-threonate promotes synaptic plasticity, which refers to the brain's ability to form and strengthen connections between neurons. This facilitates learning, memory formation, and overall cognitive performance.

  • Memory Enhancement

Magnesium L-threonate has been found to enhance the function of NMDA receptors in the brain. These receptors play a crucial role in learning and memory processes. By improving NMDA receptor activity, Magnesium L-threonate can potentially facilitate the formation and retrieval of memories. It promotes synaptic plasticity, which is vital for establishing new connections between neurons and strengthening existing ones. This enhancement of synaptic plasticity and neuronal communication can contribute to improved short-term and long-term memory. Therefore, Magnesium L-threonate may be beneficial for individuals who are experiencing difficulties with their memory and seeking to enhance their cognitive abilities.

  • Neurotransmitter Regulation

 Magnesium L-threonate plays a role in modulating neurotransmitters in the brain, including glutamate, serotonin, and dopamine. This regulation helps optimize neurotransmitter activity, which is crucial for cognitive processes such as attention, focus, and mood regulation.

  • Neuroprotection

 Magnesium L-threonate exhibits neuroprotective properties, shielding brain cells from oxidative stress and reducing the risk of age-related cognitive decline. It supports the health and integrity of brain cells, contributing to overall brain function.

  • Mental Clarity and Focus

 Magnesium L-threonate may enhance mental clarity and focus by supporting optimal brain function. It helps optimize neuronal signalling, ensuring efficient information processing and improved cognitive performance.

While research on Magnesium L-threonate is ongoing, early studies suggest its potential in improving cognitive function.

  • Potential Role in Mood Disorders

Magnesium L-threonate has shown potential in its role in mood disorders, including anxiety. Adequate magnesium levels are crucial for maintaining optimal mental health, and magnesium deficiencies have been associated with increased anxiety symptoms. Magnesium L-threonate may help alleviate anxiety by influencing neurotransmitters involved in mood regulation, such as serotonin and GABA. Serotonin is known as the "feel-good" neurotransmitter, while GABA has calming effects on the brain. By modulating these neurotransmitters, Magnesium L-threonate may help promote a sense of calm and relaxation, reducing anxiety symptoms.

Additionally, magnesium plays a role in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis, which is involved in the stress response. By supporting the proper functioning of the HPA axis, Magnesium L-threonate may help mitigate the effects of stress and anxiety. While further research is needed, preliminary findings suggest that Magnesium L-threonate may offer benefits for individuals with mood disorders, including anxiety and depression, by supporting emotional well-being and stress management. 

  • Potential Role in Neurodegenerative Diseases:

 Magnesium L-threonate has gained attention for its potential role in neurodegenerative diseases such as Alzheimer's and Parkinson's disease. While more research is needed, preliminary studies suggest several mechanisms by which Magnesium L-threonate may exert beneficial effects:

  • Alzheimer’s Disease:

Based on the findings from studies conducted on an animal model of Alzheimer's disease, Magnesium L-threonate  has demonstrated potential benefits in the context of Alzheimer’s disease. The administration of Magnesium L-Threonate has shown neuroprotective effects against oxidative stress and hippocampal neuronal apoptosis, which are important pathological mechanisms underlying cognitive deficits in Alzheimer's disease.

Additionally, in the animal model, Magnesium L-threonate treatment has been associated with improved cognitive abilities. However, further research is necessary to fully understand the mechanisms underlying the memory-protective effects of  Magnesium L-Threonate in Alzheimer’s disease. It is important to note that findings from animal studies need to be validated through additional research, including clinical trials involving human subjects, before firm conclusions can be drawn regarding the role of Magnesium L-threonate in Alzheimer's disease.

  • Parkinson’s Disease

Research suggests that Magnesium L-threonate may have a role in Parkinson's disease. In studies using animals, Magnesium L-threonate was found to reduce movement problems and protect dopamine neurons from damage caused by a toxin called MPTP, which is commonly used to mimic Parkinson’s disease. This protective effect might be due to Magnesium L-threonate increasing the level of magnesium in the cerebrospinal fluid. However, more research is needed to understand exactly how Magnesium L-threonate works in Parkinson's disease and to confirm these findings in humans. It's important to note that while these results are promising, more investigation is required before considering Magnesium L-threonate as a treatment for Parkinson’s disease.

  • Improve Sleep Quality

Magnesium L-threonate has shown potential in enhancing sleep quality. It promotes muscle relaxation and reduces tension, helping individuals prepare for sleep. By supporting the activity of GABA, an inhibitory neurotransmitter, it induces a sense of calm and aids in sleep initiation.

Magnesium L-threonate also regulates the body's internal clock, known as the circadian rhythm, promoting regular sleep-wake cycles. Additionally, it plays a role in the production of melatonin, a hormone that regulates sleep patterns. While more research is needed, Magnesium L-threonate holds promise as a supplement to improve sleep quality. Consulting a healthcare professional is recommended for personalized advice and optimal sleep management.


Magnesium L-Threonate Supplements and Dosage

Magnesium deficiency is a common problem, and many people do not obtain enough of this essential mineral through their diet. Factors like poor dietary choices, stress, certain medications, and gastrointestinal disorders contribute to magnesium deficiency. Symptoms of magnesium deficiency include fatigue, muscle cramps, sleep disturbances, and mood imbalances.

It is crucial to adhere to the recommended dosage levels in order to reap the benefits of magnesium L-thronate on cognition. While the optimal dosage can vary based on factors such as age, weight, and health status, a general recommendation is to take 1,000 to 2,000 mg of Magnesium L-Threonate per day, split into two or three doses. Magnesium L-Threonate supplementation can be an effective way to address magnesium deficiency and support cognitive function. However, it is essential to remember that individual requirements may differ, and professional guidance is crucial to determine the appropriate dosage for optimal results.


Side Effects and Drug Interactions

While Magnesium L-Threonate is generally well-tolerated, there are a few potential side effects and drug interactions to be aware of. Common side effects of magnesium supplementation, including Magnesium L-Threonate, may include diarrhea, nausea, and stomach cramps. These effects are usually mild and can be minimized by adjusting the dosage or taking the supplement with food.

Magnesium supplements, including Magnesium L-Threonate, may interact with certain medications such as antibiotics, diuretics, and medications for osteoporosis or heart conditions. These interactions can affect the absorption or effectiveness of the medications, so it is crucial to seek professional advice to prevent any potential adverse effects or reduced efficacy.


Final Thoughts

In conclusion, Magnesium L-Threonate offers numerous potential benefits for cognitive function, sleep quality, mood disorders, and overall brain health. Its unique molecular structure enables enhanced absorption and delivery of magnesium to the brain, making it a promising supplement for those seeking cognitive enhancement and support. 

If you are interested in exploring the potential benefits of Magnesium L-Threonate for yourself, we encourage you to consult with a healthcare professional to determine the appropriate dosage and to ensure it is suitable for your specific needs. They can provide personalized guidance and address any concerns or questions you may have.

Remember, taking care of your brain health is crucial for overall well-being, and Magnesium L-Threonate may be one piece of the puzzle. Invest in your cognitive function and brain health today by considering the potential benefits of Magnesium L-Threonate.


Medical Disclaimer: While we have delve into the research available on the health benefits of these awesome supplements we offer, this is for informative purposes only and shouldn’t be taken as medical advice. Those who have any health-related queries should reach out to a medical professional. These statements have not been evaluated by the Therapeutic Goods Administration. This article is not intended to diagnose, treat, cure, or prevent any disease.


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1. Xiong, Y., Ruan, Y., Zhao, J., Yang, Y., Chen, L., Mai, Y., Yu, Q., Cao, Z., Liu, F., Liao, W., & Liu, J. (2022). Magnesium-L-threonate exhibited a neuroprotective effect against oxidative stress damage in HT22 cells and Alzheimer’s disease mouse model. World Journal of Psychiatry, 12, 410 - 424.

2. Shen, Y., Dai, L., Tian, H., Xu, R., Li, F., Li, Z., Zhou, J., Wang, L., Dong, J., & Sun, L. (2019). Treatment Of Magnesium-L-Threonate Elevates The Magnesium Level In The Cerebrospinal Fluid And Attenuates Motor Deficits And Dopamine Neuron Loss In A Mouse Model Of Parkinson’s disease. Neuropsychiatric Disease and Treatment, 15, 3143 - 3153.

3. Zhang, C., Hu, Q., Li, S., Dai, F., Qian, W., Hewlings, S., Yan, T., & Wang, Y. (2022). A Magtein®, Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults. Nutrients, 14(24). 

4. Liu, C., Cheng, Y., Guo, Y., & Qian, H. (2021). Magnesium-L-threonate alleviate colonic inflammation and memory impairment in chronic-plus-binge alcohol feeding mice. Brain Research Bulletin, 174, 184-193.

5. Zhou, X., Huang, Z., Zhang, J., Chen, J. L., Yao, P. W., Mai, C. L., ... & Liu, X. G. (2021). Chronic oral administration of magnesium-L-threonate prevents oxaliplatin-induced memory and emotional deficits by normalization of TNF-α/NF-κB signaling in rats. Neuroscience bulletin, 37, 55-69.


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  • looking for Mag- L- Threonate.

    ken windrum on

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